HYPERTROPHY AND HYPERPLASIA

Difference between HYPERTROPHY and HYPERPLASIA

HYPERTROPHY HYPERPLASIA
1. Definition- Is an increase in the size of a parenchymal cell resulting in enlargement of the organ or tissue without any change in the number of cells ( increased size) Definition- This is an increase in the number of parenchymal cells resulting in enlargement of organ and tissue. (increased volume/mass)
2. Causes- Either by increased functional demand or by hormonal stimulation. (physiological or pathological).
Physiological– hypertrophy of muscle fiber due to increased workload, growth of uterus during pregnancy.Pathological– Nephrectomy on one side.

Causes- Increased recruitment of cell from G0 (G Zero) phase of the cell cycle to undergo mitosis. (physiological & pathological).
Physiological – hormonal hyperplasia, compensatory hyperplasia. Pathological – Estrogen excess.
3. Mechanism- Result of increased production of cellular protein. Mechanism- Result of growth factor-driven proliferation of the mature cell.
4. Cells affected- This occurs in non-dividing cells. Permanent cell (such as cardiac muscle, skeletal muscle) Cells affected-Occurs in dividing cells. Labile or stable cells.

 

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