Difference between HYPERTROPHY and HYPERPLASIA
|1.||Definition- Is an increase in the size of a parenchymal cell resulting in enlargement of the organ or tissue without any change in the number of cells ( increased size)||Definition- This is an increase in the number of parenchymal cells resulting in enlargement of organ and tissue. (increased volume/mass)|
|2.||Causes- Either by increased functional demand or by hormonal stimulation. (physiological or pathological).|
Physiological– hypertrophy of muscle fiber due to increased workload, growth of uterus during pregnancy.Pathological– Nephrectomy on one side.
|Causes- Increased recruitment of cell from G0 (G Zero) phase of the cell cycle to undergo mitosis. (physiological & pathological).
Physiological – hormonal hyperplasia, compensatory hyperplasia. Pathological – Estrogen excess.
|3.||Mechanism- Result of increased production of cellular protein.||Mechanism- Result of growth factor-driven proliferation of the mature cell.|
|4.||Cells affected- This occurs in non-dividing cells. Permanent cell (such as cardiac muscle, skeletal muscle)||Cells affected-Occurs in dividing cells. Labile or stable cells.|