Pathology

Dystrophic Calcification and Metastatic Calcification

Difference between Dystrophic Calcification and Metastatic Calcification

 Dystrophic CalcificationMetastatic Calcification
1.Definition- Deposits of calcium salts in dead or degenerated tissueDefinition- Deposits of calcium salts in normal tissue
2.Calcium Metabolism- NormalCalcium Metabolism- Deranged
3.Serum calcium level- NormalSerum calcium level- Hypercalcaemia
4.Reversibility- Generally irreversibleReversibility- Reversible upon correction of metabolic disorder
5.Causes- Necrosis (Caseous, liquefactive, fat), Infarct, thrombi, dead parasites, certain tumor, cystCauses- Hyperparathyroidism, prolonged immobilization, hypervitaminosis D
6.Pathogenesis- Increased binding of phosphates with necrotic & degenerative tissue which in turn binds to Calcium forming Calcium phosphate precipitatesPathogenesis- Increased precipitates of Calcium phosphate, due to hypercalcemia at certain sites eg. Lungs, stomach, blood vessels, etc.
7.Prognosis- Generally better due to little septicemiaPrognosis- Generally poor due to profound toxemia

 

Difference between Metaplasia and Dysplasia
Difference between Hypertrophy and Hyperplasia
Difference between Dry Gangrene and Wet Gangrene



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